samtools / samtools

Tools (written in C using htslib) for manipulating next-generation sequencing data

samtools / htslib

C library for high-throughput sequencing data formats

pysam-developers / pysam

Pysam is a Python package for reading, manipulating, and writing genomics data such as SAM/BAM/CRAM and VCF/BCF files. It's a lightweight wrapper of the HTSlib API, the same one that powers samtools, bcftools, and tabix.