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ai4s-research / open-science

Open Science Desktop — local-first, model-agnostic AI research workbench for macOS, Windows & Linux. Open-source Claude Science desktop alternative built on Tauri + MCP + agent skills.

▲ ~147/7d ★ 2.0k TypeScript today
SakanaAI / AI-Scientist-v3

The Agentic Scientist: Orchestrating Coding Agents for Automated Scientific (Co-)Discovery

▲ ~84/7d ★ 479 Python 5d ago
mikamikasuki / forest

FOREST is a research agent for long-horizon science, where evidence gets lost, errors compound, and goals drift. It explores ideas, reads literature, forms hypotheses, runs real experiments, analyzes results, revises paths, and builds a full paper—all in an editable graph you can inspect, branch, redirect, with claims and figures linked to evidence

▲ ~63/7d ★ 331 Python today
foryourhealth111-pixel / Vibe-Skills

Intelligent Skill routing and workflow orchestration for AI agents — +21.12 pp reward, −29.6% tokens on SkillsBench with DeepSeekV4Flash-VE.

▲ ~46/7d ★ 3.8k Python 1d ago
openags / paper-search-mcp

MCP, CLI, Skills for searching and downloading academic papers from multiple sources like arXiv, PubMed, bioRxiv, etc.

▲ ~44/7d ★ 2.9k Python 22d ago
K-Dense-AI / k-dense-byok

An AI co-scientist running on your desktop. Claude Science but better.

▲ ~24/7d ★ 1.4k TypeScript 7d ago
tsinghua-fib-lab / AgentSociety

AgentSociety 2 is a modern, LLM-native agent simulation platform designed for social science research and experimental design. It provides a flexible framework for creating and managing intelligent agents in simulated environments.

▲ ~19/7d ★ 1.4k Python 3d ago
ruc-datalab / DeepAnalyze

DeepAnalyze is the first agentic LLM for autonomous data science. 🎈你的AI数据分析师,自动分析大量数据,一键生成专业分析报告!

▲ ~16/7d ★ 4.7k Python 11d ago
xonsh / xonsh

🐚 Python-powered shell. Full-featured, cross-platform and AI-friendly.

▲ ~10/7d ★ 9.7k Python 1d ago
jimmc414 / Kosmos

Kosmos: An AI Scientist for Autonomous Discovery - An implementation and adaptation to be driven by Claude Code or API - Based on the Kosmos AI Paper - https://arxiv.org/abs/2511.02824

▲ ~9/7d ★ 601 Python 15d ago
apache / hamilton

Apache Hamilton helps data scientists and engineers define testable, modular, self-documenting dataflows, that encode lineage/tracing and metadata. Runs and scales everywhere python does.

▲ ~7/7d ★ 2.6k Jupyter Notebook 1d ago
rashakil-ds / Roadmap-Docs

Best Data Science, Data Analytics, AI, and SDE roadmaps. This repository is continually updated based on the top job postings on LinkedIn and Indeed in the data science and AI domain.

▲ ~7/7d ★ 1.1k 2d ago
xuzhougeng / wisp-science

Open-source, local-first desktop AI research workbench for scientific computing with Python/R, MCP bioinformatics tools, SSH/WSL/GPU runtimes, and OpenAI/Anthropic models.

▲ ~7/7d ★ 1.1k Rust today
github / scientist

:microscope: A Ruby library for carefully refactoring critical paths.

▲ ~4/7d ★ 7.8k Ruby 1d ago
retentioneering / retentioneering-tools

Python toolkit, MCP server, and agent skills for reproducible, auditable clickstream and event log analytics. Helps AI agents, data scientists and analysts build, validate, and cross-check product analytics, quantitative UX, customer journeys, graph-based user flows, behavioral segmentation, A/B tests, process mining models, Markov chain simulation

▲ ~4/7d ★ 937 Python today
sagirimo / BioDSH

The bioinformatics agent desktop for clinicians and wet-lab scientists — built on DeepSeek Harness. One-click installers, a skill store, offline mode.

▲ ~4/7d ★ 63 Python 1d ago
NetLogo / NetLogo

turtles, patches, and links for kids, teachers, and scientists

▲ ~2/7d ★ 1.2k Scala today
kubeflow / kale

Kubeflow’s superfood for Data Scientists

▲ ~2/7d ★ 707 Python 5d ago
GACWR / OpenUBA

A robust, and flexible open source User & Entity Behavior Analytics (UEBA) framework used for Security Analytics. Developed with luv by Data Scientists & Security Analysts from the Cyber Security Industry. [BETA]

▲ ~2/7d ★ 523 Python 7d ago
Tyche-MKR / scientific-agent-skills

Turn any AI agent into an AI Scientist. The #1 Agent Skills library for science, used by 190,000+ scientists worldwide. 165 ready-to-use validated skills plus 100+ scientific databases covering biology, chemistry, medicine, and drug discovery. Compatible with Cursor, Claude Code, Codex, Pi, Antigravity, and the open Agent Skills standard.

▲ ~2/7d ★ 82 Python 1mo ago
outerloop-science / outerloop

Autoresearch agents that improve your benchmark: independent re-measurement, enforced budgets, results as pull requests

▲ ~2/7d ★ 37 Python today
jkitchin / scimax

An emacs starterkit for scientists and engineers

▲ ~0/7d ★ 1.1k Emacs Lisp 3d ago
apache / bigtop

Bigtop is an Apache Foundation project for Infrastructure Engineers and Data Scientists looking for comprehensive packaging, testing, and configuration of the leading open source big data components.

▲ ~0/7d ★ 682 Groovy 26d ago
yogsoth-ai / de-anthropocentric-research-engine

Give an AI a research direction: it runs literature synthesis, gap validation, hypothesis formation and experiment design itself. 267 markdown skills form a research graph: 51 operations built from 216 atomic steps, any order, explicit backtracking; the plan is approved before it runs and interrupted runs resume. npx install, no runtime, no API key

▲ ~0/7d ★ 505 1d ago
sammargolis / DrugTargetWorld

DrugTargetWorld: a synthetic biobank for training and benchmarking AI scientists on end-to-end drug target discovery. Paper: arXiv:2610.09558

▲ ~0/7d ★ 34 13d ago
EvoScientist / SearchJev

SearchJev: a fast and calibrated System-1 model for search agents (training code)

▲ ~0/7d ★ 34 Python 19d ago
Xavier-168 / data-scientist-community

Local-first macOS creator analytics for Douyin, Xiaohongshu, Bilibili and Kuaishou, with Excel export and optional Feishu sync.

▲ ~0/7d ★ 32 Python 1mo ago
Scientist888-star / GDAFusion

[Pattern Recognition 2026] Generative Representation Learning with Information Disentanglement and Global Alignment for Infrared and Visible Image Fusion

▲ ~0/7d ★ 30 Python 2mo ago
OpenNSWM-Lab / FAROS

A blueprint-driven AutoResearch runtime for orchestrating AI research workflows from idea generation and experiments to paper writing and peer review.

▲ ~-16/7d ★ 3.0k Python 2d ago
damonwan1 / AutoScholarLoop

A multi-agent AUTO Research loop for idea discovery, experiment execution, evidence-grounded paper writing, quality audit, and live Web observation from AI group, CNIC, CAS.

▲ ~-72/7d ★ 534 Python 1mo ago