nirmaljosephukken / pylon-player
A calmer, redesigned media player built on the VLC engine, for Windows, Linux and macOS. Hover-only controls, seek bar previews, a music library, a drag-to-sync subtitle timeline, per-show presets, themes and auto-updates. Based on Juxtopposed's VLC redesign.
XiaoYouChR / Ghost-Downloader-3
The only downloader you need. 下载器的集大成者。
ScottSloan / Bili23-Downloader
开源、免费、跨平台的 B 站视频下载工具，支持多线程加速、音视频分离、弹幕元数据获取、自定义命名与分类等功能。Open Source, Free, Cross-Platform Bilibili Video Downloader.
zhiyiYo / PyQt-Fluent-Widgets
A fluent design widgets library based on C++ Qt/PyQt/PySide. Make Qt Great Again.
tonquer / picacg-qt
哔咔漫画, PicACG comic PC client(Windows, Linux, MacOS)
oop7 / YTSage
Modern YouTube downloader with a clean PySide6 interface. Download videos in any quality, extract audio, fetch subtitles, sponsorBlock, and view video metadata. Built with yt-dlp for reliable performance.
tonquer / JMComic-qt
禁漫天堂，18comic，使用qt实现的PC客户端，支持Windows，Linux，MacOS
RubinLabs26 / ISpotify
Local-first desktop music search, playlist, download, and playback app for Windows and Linux
muziing / PySide6-Code-Tutorial
可能是最好的PySide6中文教程！用代码实例讲解PySide6，附优质Demos、图标库、QSS皮肤、相关文章等分享！
chenmozhijin / LDDC
简单易用的精准歌词(逐字歌词/卡拉OK歌词)下载匹配工具|A simple and user-friendly tool for downloading and matching precise lyrics (word-by-word lyrics/Karaoke lyrics)
Capsize-Games / airunner
Offline inference engine for art, real-time voice conversations, LLM powered chatbots and automated workflows
bpozdena / OneDriveGUI
A simple GUI for OneDrive Linux client with multi-account support.
hishizuka / pizero_bikecomputer
An open-source bike computer with GPS and ANT+ capabilities, based on the Raspberry Pi Zero (W, WH, 2 W) or the Compute Module Zero (CM0). It also includes offline maps and navigation.
ChaozhongLiu / DyberPet
Desktop Cyber Pet Framework based on PySide6
mottosso / Qt.py
Minimal Python 2 & 3 shim around all Qt bindings - PySide2, PySide6, PyQt5 and PyQt6.
nwutils / Web2Executable
Uses NW.js to generate "native" apps for already existing web apps.
RareDevs / Rare
Rare is an open source alternative for Epic Games Launcher, using Legendary.
5yutan5 / PyQtDarkTheme
A flat dark theme for PySide and PyQt.
Hyacinthe-primus / File_Converter_Pro
Free offline all-in-one file converter for Windows. Converts documents, images, audio and video locally. No uploads, no internet, no dependencies. Built with Python & PySide6. Features dark/light theme, stats dashboard, achievements, and multi-engine fallback.
123panNextGen / 123pan
第三方123云盘客户端，解决了123云盘官方客户端的若干问题，并使用多种方式解除部分流量限制，使用Python3和PyQt6制作
ColdWindScholar / MIO-KITCHEN-SOURCE
An Android Rom Tool in python
Matteo842 / SaveState
Free open-source game save backup manager for Windows & Linux. Drag & drop a launcher shortcut to set up a game; auto-finds saves for Steam, Epic, GOG and 28+ emulators (RetroArch, Dolphin, Yuzu...). Desktop shortcuts for one-click backup, zip rotation, optional cloud sync.
l5769389 / voxenra
Cross-platform DICOM viewer for CT, MRI & PET/CT with MPR, 3D, fusion, editable segmentation and local AI auto-segmentation via TotalSegmentator.
songconmaisaix31-design / mcpet
把写代码时的 AI 搭子换上麦当劳制服，养在桌面角落：11:30 喊你干饭、汇报最划算的券、用营养数据把关；跑长任务时同步项目进度与 token 余额。
CheshireMew / VoxWeave
Local-first high-quality offline RVC voice conversion workstation
jaikydota / kk-mix
Windows 批量视频混剪工具，15 项批处理功能 | A Windows batch video editing toolkit — 15 batch operations.
karuvanan / MiniMax-H3-Director-Cut-Studio
Premiere-inspired PySide6 director studio for MiniMax H3 Ref2VA with AI shot planning, semantic media enrichment, timeline prompt reconciliation and shot-aware long-video rendering through ComfyUI.
hety0211 / lumen-raw
开源多品牌 RAW 照片编辑器，集调色、AI 增强、智能蒙版与照片合成于一体。 / An open-source multi-brand RAW photo editor with color grading, AI enhancement, smart masks, and photo merging.
Aiyawoc / CodexSessionManager
Safety-first GUI and CLI for auditing, backing up, importing, cleaning, and trimming Codex conversations without editing internal storage.
Eifptaur / Eif-MAPT-PersonaMorph
Windows 微信群聊机器人：按设定人设回复群消息，本地运行、接入你自己的模型 API。控制台为原生桌面窗口（27 个面板），发消息/切会话/发图/发表情走后台投递——不动鼠标、不要求微信窗口可见。非官方产品，与腾讯无关。
hclivess / whisperer
Batch subtitle generator GUI for video/audio — Whisper via faster-whisper or whisper.cpp (PySide6)
NguyenSiTrung / VieNeuTTSApp
Cross-platform, fully-offline Vietnamese/English text-to-speech desktop workstation powered by VieNeu-TTS v3 Turbo (ONNX/CUDA, Voice Cloning, EPUB Audiobooks, PySide6/QML)
fan138 / WatuDisk
挖兔硬盘精灵 —— 免费无广告的 Windows 硬盘健康守护：SATA/NVMe 检测 · 六档颜色预警 · 开机静默体检 · 一键 HTML 报告 · 单文件绿色版
preppie22 / gogstash
A desktop GUI application for downloading local backups of your GOG.com game library
GLFzr / QianBi-Novel
千笔一文 Novel — 人 AI 共写的长篇网文创作台：条目化世界书 · 正则 must 契约（确定性复检，违规拦住锁定）· 三层审校（引证验真 + 投票）· 同人文外部导入可整批撤销 · 升级不动书稿 · BYOK 全本地 · MIT。A long-form fiction co-writing agent whose pipeline knows how to say no.
tokyoxpa3 / NetRedirector
Windows 網路流量轉發與代理工具：WinDivert 驅動層封包攔截、多進程攔截規則、多網卡路由與故障轉移、IPv6 雙棧、SOCKS5/HTTP 代理、PySide6 即時監控介面 (MIT)
TheJustRun / PiraChest
An all-in-one desktop app for discovering, downloading, and managing games, ROMs, music, anime, books, TV, YouTube videos, and more. Browse multiple sources, manage downloads, stream supported media, and keep everything organized in one modern interface. Currently in alpha and actively being developed.
crazymsn / SubFlow
SubFlow 语幕 — 新一代 AI 视频语音识别、AI 配音、自动翻译、字幕生成工具
KKPIP-Tech / InstructionX_UIKit
InstructionX UIKit：基于 PySide6 的交互组件库，为 InstructionX 提供界面支持，独立维护。PySide6-based UI component library for InstructionX, independently maintained.
erenciracioglu-dotcom / hermes-desktop-avatar
Always-on-top desktop sprite avatar UI shell for a local Hermes Agent gateway. PySide6, OpenAI-compatible HTTP API.
AliMilani / samovar-lite
PotPlayer-style media player for Linux, built on libmpv and Qt. Drop a video, load a subtitle, familiar shortcuts.
NOTBAD314 / 2ByteASR
兔白字幕：面向中文游戏实况的本地字幕识别与视频编辑工具，支持校对、说话人分轨与特效字幕。当前提供源码，暂无公开安装包。
MuzeAnisichael / LinguaRelay
Real-time Windows system-audio translation captions for Chinese, Japanese, English, and Korean, with optional LLM revision.
VIKINGYFY / OWRT-Tools
PySide6 GUI for building OpenWrt on Linux and WSL2
QCYTSN / ds-local-pet
Lightweight, offline-first DeepSeek 大肥鱼 desktop pet for Windows, built with PySide6.
arewoz / ExileLens
Free, open-source PoE2 item comparison tooltip powered by your PoB2 build. Support development via Patreon.
laoziocean-code / ai-photo-manager
AI摄影管家：从海量照片自动精选好照片（本地预处理 + AI 视觉评分 + 智能精选 + 摄影报告），支持 Windows / macOS / 手机版
MaverickRox / VRKA
Lightweight, resilient desktop media downloader for Windows with Qt 6 QML interface, strict-FIFO task scheduling, and passive browser fallback
cramen / modbus_connector
Cross-platform Modbus toolkit (PySide6): master client with register table, polling, live graphs, alarms and bus scanner; device simulator (slave) with register map and expression rules; passive RTU sniffer. EN/RU UI.
Gacut / OpenTrace
Offline desktop workspace for organizing OSINT investigations.
Garionhk / RTX-VSR-Studio
Windows GUI and CLI for upscaling video with NVIDIA RTX Video Super Resolution (no ComfyUI or PyTorch needed). Resumable segments for long films, batch queue, before/after preview, 720p–4K presets that keep aspect ratio, H.264/HEVC/ProRes/DNxHR output, never overwrites.
zhangzhendan-Berkeley / UCAS-Desktop
国科大 Windows 桌面助手：托盘后台运行、轻新课堂、讲座预约、选课规划与自动化、国科大在线视频/PDF；模块化集成与详细使用说明。